11332

Atropine sulfate salt monohydrate

tested according to Ph. Eur.

• 동의어(들): Atropini sulfas, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate
• Linear Formula: (C₁₇H₂₃NO₃)₂ · H₂SO₄ · H₂O
• CAS Number: 5908-99-6
• Molecular Weight: 694.83
• Beilstein: 6109275
• EC Number: 200-235-0
• MDL number: MFCD00074815
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329749385
• NACRES: NA.21

속성

• Agency: USP/NF; tested according to Ph. Eur.
• Quality Level: 200
• mp: 189-192 °C (A) (lit.)
• solubility: water: soluble 2500 g/L at 4 °C
• 응용 분야: pharmaceutical (small molecule)
• SMILES string: O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6
• InChI: 1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;
• InChI key: JPKKQJKQTPNWTR-CHYDPLAESA-N
• 유전자 정보: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

설명

애플리케이션

Atropine sulfate salt monohydrate has been used for anaesthetizing mice for intranasal administration of ropinirole or 7-OH-DPAT.

생화학적/생리학적 작용

Atropine sulfate salt monohydrate is a competitive nonselective antagonist of central and peripheral muscarinic acetylcholine receptors. Atropine is a cholinergic receptor antagonist isolated from Atropa belladona L., Datura stramonium L. and other plants of the solanaceae family. It blocks the ion currents mediated by neuronal nicotinic acetylcholine receptors. Further, it blocks the acetylcholine (ACh)-induced relaxations in human pulmonary veins.

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H330
• 예방조치 성명서: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges