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Merck
모든 사진(1)

Key Documents

SCT092

Sigma-Aldrich

BioTracker PyrPeg Amyloid-b Live Cell Dye

동의어(들):

BioTracker PyrPeg Amyloid-b Live Cell Dye

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About This Item

UNSPSC 코드:
12352207
NACRES:
NA.47

형태

lyophilized

분자량

calculated mol wt 459.49

포장

pkg of 1 mg

제조업체/상표

Millipore

저장 조건

protect from light

성장 모드

N/A

배송 상태

ambient

저장 온도

−20°C

일반 설명

Alzheimer′s disease (AD) is a progressive neurological disorder characterized by the presence of amyloid-beta (Aβ) plagues and neurofibrillary tangles. The accumulation of Aβ plaques is an early event in the pathogenesis of AD. In AD research, there has been a growing need for in vivo Aβ imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging. BioTracker PyrPeg Amyloid-b Live Cell Dye is a two-photon fluorescent probe that specifically detects insoluble Aβ, rather than tau and alpha-synuclein aggregates (1). This probe may serve as a useful blood-brain-barrier penetrating tool for optical and functional monitoring of insoluble forms of Aβ aggregates in the AD model brain (1).Reference:1. Choi, Ji-Woo, et al. "PyrPeg, a Blood–Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates." ACS Chemical Neuroscience 11.12 (2020): 1801-1810.

애플리케이션

Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.

특징 및 장점

Two-photon fluorescent probe for imaging insoluble forms of Amyloid-beta aggregates in Alzheimer′s disease studies.

물리적 형태

Lyophilized. Orange solid.

저장 및 안정성

Store at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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