MABT179

Anti-Osterix (SP7) Antibody, clone 6B12.1

clone 6B12.1, from mouse

• 동의어(들): Transcription factor Sp7, Zinc finger protein osterix
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: 6B12.1, monoclonal
• 종 반응성: human, rat
• 기술: immunohistochemistry: suitable; western blot: suitable
• 동형: IgMκ
• NCBI 수납 번호: NP_001166938
• UniProt 수납 번호: Q8TDD2
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SP7(121340)

설명

일반 설명

OSTERIX, or SP7, is a zinc finger-containing, osteoblast-specific transcription factor that is distinctly expressed in all developing bones, and is a key requirement for the differentiation of pre-osteoblasts into fully functional osteoblasts. While research on the actual functional mechanisms of OSTERIX is still on-going, current findings indicate that OSTERIX expression is induced by BMP-2 and Dlx5, and operates downstream of RUNX2, supporting its role in mesenchymal stem cell differentiation. Further studies also indicate that the OSTERIX transcription factor may also play a role in negatively regulating the Wnt/β-catenin signaling pathways and the proliferation of osteroblast cell types during embryonic osteogenesis.

면역원

GST-tagged recombinant protein corresponding to human Osterix.

애플리케이션

Detect the Osterix (SP7) protein using this Anti-Osterix (SP7), clone 6B12.1 validated for use in WB & IHC.

Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected Isocitrate dehydrogenase in rat tooth tissue. Nuclear staining may be observed in epithelial cells in some tissues.

Research Category
Cell Structure

Research Sub Category
Cytoskeletal Signaling

품질

Evaluated by Western Blotting in SW1353 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Osterix in 10 µg of SW1353 cell lysate.

표적 설명

~45 kDa observed. An uncharacterized band may appear at ~160 kDa in some lysates.

물리적 형태

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
SW1353 cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable