MABS481

Anti-PL Scramblase 3, clone 3B4 Antibody

clone 3B4, from mouse

• 동의어(들): Phospholipid scramblase 3, PL scramblase 3, Ca(2+)-dependent phospholipid scramblase 3
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 3B4, monoclonal
• 종 반응성: human, mouse
• 기술: western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_001161969
• UniProt 수납 번호: Q9JIZ9
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PLSCR3(57048)

설명

일반 설명

Phospholipid scramblase 3 (PL scramblase 3), also known as Ca(2+)-dependent phospholipid scramblase 3, and encoded by the gene name PLSCR3, is a member of the phospholipid scramblase family. Recent studies have indicated that PL scramblase 3 may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. PL scramblase 3 is suggested to play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. It may also play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. PL scramblase 3 has been demonstrated to interact with PDCD6 in a calcium-dependent manner.

면역원

Recombinant protein corresponding to human PL Scramlase 3.

애플리케이션

This Anti-PL Scramblase 3 antibody is validated for use in Western Blotting for the detection of PL Scramblase 3.

Western Blotting Analysis: A representative lot detected PL Scramlase 3 in SH-SY5Y cell lysate (Chu, C.T., et al. (2013). Nature Cell Biology. 15(10):1197-1205).
Western Blotting Analysis: A representative lot detected PL Scramlase 3 in primary adipocytes lysate (Wiedmer, T., et al. (2004). PNAS. 101(36):13296-13301).

품질

Evaluated by Western Blotting in NIH-3T3/L1 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected PL Scramlase 3 in 10 µg of NIH-3T3/L1 cell lysate.

표적 설명

~31 kDa observed

물리적 형태

Format: Purified

기타 정보

Concentration: Please refer to lot specific datasheet.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1