MABS430

Anti-Mcpip1, clone 2H8.2 Antibody

clone 2H8.2, from mouse

• 동의어(들): Mcpip1, Ribonuclease ZC3H12A, MCP-induced protein 1, Zinc finger CCCH domain-containing protein 12A
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 2H8.2, monoclonal
• 종 반응성: human
• 기술: immunohistochemistry: suitable (paraffin); western blot: suitable
• 동형: IgG2aκ
• NCBI 수납 번호: NP_079355
• UniProt 수납 번호: Q5D1E8
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ZC3H12A(80149)

설명

일반 설명

MCP-induced protein 1 (also known as ribonuclease ZC3H12A, Zinc finger CCCH domain-containing protein 12A) is encoded by the ZC3H12A gene in human (also known as dJ423B22.1, MCPIP, MCPIP1). It belongs to the 4-member CCCH-zinc finger protein family (MCPIP1/2/3/4) that act as negative regulators in macrophage activation (PMID 18178554). MCPIP1 in particular is involved in immune response downregulation upon LPS treatment by targeting IL-6 and IL-12b with its RNase activity (PMID 22561375). MCPIP1 expresssion by MCP-1 treatment is reported to promote angiogenesis in human umbilical vein endothelial cell (HUVEC) cultures, while causing apoptotic cell death in cardiac myocytes (PMID 18364357 & 16574901).

면역원

GST-tagged recombinant protein corresponding to human Mcpip1.

애플리케이션

Anti-Mcpip1, clone 2H8.2 Antibody is an antibody against Mcpip1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MCPIP1 in human kidney tissue.

품질

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected MCPIP1 in 10 µg of THP-1 cell lysate.

표적 설명

~65 kDa observed

물리적 형태

Format: Purified

기타 정보

Concentration: Please refer to lot specific datasheet.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable