MABS1276
Anti-TRAP-1 Antibody, clone TR-1
clone TR-1, from mouse
동의어(들):
Heat shock protein 75 kDa, mitochondrial, TRAP-1, HSP 75, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP-1
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모든 사진(2)
About This Item
UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
TR-1, monoclonal
종 반응성
human
기술
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
동형
IgG2aκ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... TRAP1(10131)
일반 설명
Heat shock protein 75 kDa, mitochondrial (UniProt Q12931; also known as HSP 75, TNFR-associated protein 1, TRAP-1, Tumor necrosis factor type 1 receptor-associated protein) is encoded by the TRAP1 (also known as HSP75) gene (Gene ID 10131) in human. The mammalian HSP70 family consists of the mitochondrial HSP75 (TRAP-1), the endoplasmic HSP78, the cytoplasmic HSC70 (a.k.a. HSC73 and HSP73) and its inducible counterpart HSP72 (a.k.a. HSP70). TRAP-1 regulates a metabolic switch between oxidative phosphorylation and aerobic glycolysis. TRAP1-deficiency results in enhanced mitochondrial respiration and fatty acid oxidation, as well as increased cellular accumulation of tricarboxylic acid cycle intermediates, ATP, and reactive oxygen species species. TRAP-1-deficient cells display suppressed glucose metabolism and strikingly enhanced invasiveness, implicating a tumor suppressor role of TRAP-1.
면역원
Recombinant protein corresponding to human TRAP-1.
애플리케이션
Anti-TRAP-1 Antibody, clone TR-1 is an antibody against TRAP-1 for use in Western Blotting, Immunohistochemistry (Paraffin), Immunoprecipitation.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRAP-1 in normal human bladder and human bladder cancer tissue.
Western Blotting Analysis: A representative lot detected TRAP-1 primarily in the inner mitochondrial membrane (IMM) and mitochondrial matrix (Mx), but not the outer mitochondrial membrane (OMM) or the intermembrane space (IMS) of fractionated mitochondria preparations from HeLa cells (Yoshida, S., et al. (2013). Proc. Natl. Acad. Sci. U. S. A. 110(17):E1604-E1612).
Western Blotting Analysis: A representative lot detected TRAP-1 primarily in the inner mitochondrial membrane (IMM) and mitochondrial matrix (Mx), but not the outer mitochondrial membrane (OMM) or the intermembrane space (IMS) of fractionated mitochondria preparations from HeLa cells (Yoshida, S., et al. (2013). Proc. Natl. Acad. Sci. U. S. A. 110(17):E1604-E1612).
Research Category
Signaling
Signaling
품질
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected TRAP-1 in 10 µg of HeLa cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected TRAP-1 in 10 µg of HeLa cell lysate.
표적 설명
~75 kDa observed
물리적 형태
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
기타 정보
Concentration: Please refer to lot specific datasheet.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Soichiro Yoshida et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), E1604-E1612 (2013-04-09)
TRAP1 (TNF receptor-associated protein), a member of the HSP90 chaperone family, is found predominantly in mitochondria. TRAP1 is broadly considered to be an anticancer molecular target. However, current inhibitors cannot distinguish between HSP90 and TRAP1, making their utility as probes
Kiran Kurmi et al.
Cell metabolism, 28(6), 833-847 (2018-09-04)
How mitochondrial metabolism is altered by oncogenic tyrosine kinases to promote tumor growth is incompletely understood. Here, we show that oncogenic HER2 tyrosine kinase signaling induces phosphorylation of mitochondrial creatine kinase 1 (MtCK1) on tyrosine 153 (Y153) in an ABL-dependent manner
S J Felts et al.
The Journal of biological chemistry, 275(5), 3305-3312 (2000-02-01)
The hsp90 family of molecular chaperones was expanded recently due to the cloning of TRAP1 and hsp75 by yeast two-hybrid screens. Careful analysis of the human TRAP1 and hsp75 sequences revealed that they are identical, and we have cloned a
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