MABN41

Anti-Sodium channel Nav1.7 Antibody, clone N68/6

clone N68/6, from mouse

• 동의어(들): sodium channel, voltage-gated, type IX, alpha subunit, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, Peripheral sodium channel 1, sodium channel, voltage-gated, type IX, alpha polypeptide, Nav1.7, sodium
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: N68/6, monoclonal
• 종 반응성: rat, human
• 기술: immunohistochemistry: suitable; western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_002968
• UniProt 수납 번호: Q15858
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified

설명

일반 설명

Voltage-gated sodium channel subunit alpha Nav1.7 (Nav1.7) is a multi-pass membrane protein containing a single IQ domain that belongs to the sodium channel family. NAV1.7 localizes to the terminal ends of sensory neurons and is believed to have a role in inflammatory pain development and mechanisms. It serves to regulate excitable membrane voltage-dependent Na+ ion permeability. There is a strong probability that Nav1.7 is involved in the transmission of nociceptive information, a suggested involvement supported by its role in a variety of chronic pain neuropathies induced by damage to the peripheral nerves. Nav1.7 is predominantly observed in dorsal root ganglion, and sensory and sympathetic neurons. Lower levels of the protein have been observed in MTC cell line, C-cell carcinoma, and smooth muscle cells. Defects in Nav1.7 expression are causal to several diseases such as autosomal recessive congenital indifference pain, primary erythermalgia, and paroxysmal extreme pain disorder or PEPD.

면역원

Recombinant protein corresponding to human Nav1.7.

애플리케이션

Research Category
Neuroscience

Signaling

Research Sub Category
Signaling Neuroscience

This Anti-Sodium channel Nav1.7 Antibody, clone N68/6 is validated for use in IH, WB for the detection of Sodium channel Nav1.7.

Western Blot Analysis: A previous lot was used by an independent laboratory in HEK293 cell lysate. (James Trimmer, UC Davis/NIH NeuroMab Facility, Department of Neurobiology, Physiology and Behavior, UC Davis, Davis CA 95616-8519. neuromab@ucdavis.edu.)

품질

Evaluated by Immunohistochemistry in rat cerebellum tissue.

Immunohistochemistry Analysis: 1:400 dilution of this antibody detected Nav1.7 in rat cerebellum tissue.

표적 설명

Observed at ~ 230 kDa

물리적 형태

Format: Purified

Protein G

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Rat cerebellum tissue

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable