C2993

Anti-CRMP2 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-Collapsin Response Mediator Protein 2, Anti-Dihydropyriminidase Related Protein-2 (DRP2, DRP-2, DHPRP2), Anti-Dihydropyriminidase-like 2 (DPYSL2), Anti-TOAD-64
• MDL number: MFCD03456049
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen ~62 kDa
• 종 반응성: human, mouse, rat
• 향상된 검증: recombinant expression; Learn more about Antibody Enhanced Validation
• 농도: ~1.0 mg/mL
• 기술: western blot: 0.1-0.2 μg/mL using HeLa whole cell lysate and mouse brain extract (S1 fraction)
• UniProt 수납 번호: Q16555
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... DPYSL2(1808) ; mouse ... Dpysl2(12934) ; rat ... Dpysl2(25416)

설명

일반 설명

Collapsin response mediator proteins CRMPs) consist of a family of cytosolic phosphoproteins expressed in the nervous system and involved in neuronal differentiation and axonal guidance.

애플리케이션

Anti-CRMP2 antibody produced in rabbit has been used in:

• western blotting
• immunohistofluorescence
• epifluorescence imaging
• coimmunoprecipitation

생화학적/생리학적 작용

CRMPs are a part of the collapsin/semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. CRMP2 is upregulated during development, and appears to be crucial for axon outgrowth. Glycogen synthase kinase 3 beta (GSK-3b) phosphorylates and inactivates CRMP-2 downstream of the phosphoinositide-3-kinase (PI3K/Akt) pathway, thus regulating neuronal polarity. CRMP2 interacts with tubulin dimers, kinesin-1 and WASP-family verprolin homologous protein 1 (WAVE1) complex to regulate axon outgrowth.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable