MAB5432

Anti-CREB Antibody

Chemicon^®, from mouse

• 동의어(들): cAMP-response Element Binding Protein
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: monoclonal
• 종 반응성: human, mouse, rat
• 제조업체/상표: Chemicon^®
• 기술: ELISA: suitable; western blot: suitable
• 동형: IgG1
• NCBI 수납 번호: NM_004379.2; NM_134442.2
• UniProt 수납 번호: P16220
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CREB1(1385)

설명

일반 설명

CREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. CREB promotes outgrowth and differentiation as a mediator of Neurotrophin pathways. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling.

특이성

Reacts with CREB.

면역원

Recombinant CREB-A protein.

애플리케이션

Anti-CREB Antibody is a Mouse Monoclonal Antibody for detection of CREB also known as cAMP-response Element Binding Protein & has been validated in ELISA & WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Western blot: 1-5 μg/mL. Recognizes the ~43kDa protein.

ELISA: 0.1-1.0 μg/mL

Optimal working dilutions must be determined by end user.

결합

Replaces: 04-218

물리적 형태

Format: Purified

Purified immunoglobulin. Liquid in PBS containing 0.1% sodium azide.

저장 및 안정성

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.

분석 메모

Control
Jurkat nuclear extract, A-431 whole cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable