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Merck
모든 사진(1)

주요 문서

MAB3319

Sigma-Aldrich

Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6

clone 114-6G6, Chemicon®, from mouse

동의어(들):

MT1-MMP

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

114-6G6, monoclonal

종 반응성

human

반응하면 안 됨

pig, rat, mouse

제조업체/상표

Chemicon®

기술

ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

동형

IgG1κ

NCBI 수납 번호

UniProt 수납 번호

배송 상태

dry ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... MMP14(4323)

특이성

The antibody specifically reacts with human MT1-MMP. This is a purified mouse monoclonal antibody to an oligopeptide of REVPYAYIREGHEK (residue 160-173) on human membrane-type 1 matrix metalloproteinase (human MT1-MMP) and does not react with mouse or rat. However, this sequence is identical in mouse and rat MT1-MMP. For unknown reasons this antibody does not react on westerns to CC1043.

면역원

Epitope: catalytic domain

애플리케이션

Immunoblotting: 8-20 μg/mL. 66+60kDa (Ueno et al., 1997)

Immunohistochemistry on paraffin-embedded tissue sections, use at 20 μg/mL concentration (see Ueno et al., 1997; Nakamura et al., 1999). Requires periodate-lysine-paraformaldehyde fixative (Namura et al., 1999) for 18-24 hrs. at 4°C.

EIA Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
MMPs & TIMPs
This Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6 is validated for use in ELISA, WB, IH(P) for the detection of MMP-14.

물리적 형태

Format: Purified
Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin.

저장 및 안정성

Maintain frozen at -20°C in undiluted aliquots for up to 12 months.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Manufactured by Daiichi Fine Chemical Co., Ltd

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
Katarzyna Starska, Olga Stasikowska, Marek Lukomski, Iwona Lewy-Trenda
Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego null
Yongping Li et al.
American journal of translational research, 7(1), 120-127 (2015-03-11)
Membrane type 1 matrix metalloproteinase (MT1-MMP) has been demonstrated to play an important role in tumor progression. The aim of the present study was to analyze the expression of MT1-MMP in breast cancer and its correlation with clinicopathologic characteristics, including
Bo-Ra Son et al.
Stem cells (Dayton, Ohio), 24(5), 1254-1264 (2006-01-18)
Human mesenchymal stem cells (MSCs) are increasingly being considered in cell-based therapeutic strategies for regeneration of various organs/tissues. However, the signals required for their homing and recruitment to injured sites are not yet fully understood. Because stromal-derived factor (SDF)-1 and
Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation.
Mu?oz-Najar, UM; Neurath, KM; Vumbaca, F; Claffey, KP
Oncogene null
Dae-Il Chang et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 23(12), 1408-1419 (2003-12-10)
During focal cerebral ischemia, matrix metalloproteinase-2 (MMP-2) can contribute to the loss of microvessel integrity within ischemic regions by degrading the basal lamina. MMP-2 is secreted in latent form (pro-MMP-2), but the activation of pro-MMP-2 in the ischemic territory has

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