MAB2239

ANTI-TAU (MAPT) Antibody

mouse monoclonal, Tau 7

• 동의어(들): G protein beta1/gamma2 subunit-interacting factor, Neurofibrillary tangle protein, Paired helical filament-tau, microtubule-associated protein tau, microtubule-associated protein tau, isoform 4
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 제품명: Anti-Tau Antibody, clone Tau 7, clone Tau 7, from mouse
• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: Tau 7, monoclonal
• 종 반응성: human, rat
• 기술: western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_001116538.1
• UniProt 수납 번호: P10636
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... MAPT(4137) ; rat ... Mapt(29477)

설명

일반 설명

Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.

특이성

Cat. # MAB2239 recognizes the C-terminus region of Tau.

Reactivity with other species has not been determined.

애플리케이션

This Anti-Tau Antibody, clone Tau 7 is validated for use in WB for the detection of Tau.

품질

Western Blot:

표적 설명

50-68 kDa

물리적 형태

Format: Purified

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable