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Key Documents

MAB1596

Sigma-Aldrich

Anti-Post Synaptic Density Protein 95 Antibody, clone 6G6-1C9

clone 6G6-1C9, Chemicon®, from mouse

동의어(들):

PSD-95

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

6G6-1C9, monoclonal

종 반응성

mouse, rat, bovine

제조업체/상표

Chemicon®

기술

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

동형

IgG2a

NCBI 수납 번호

UniProt 수납 번호

배송 상태

dry ice

타겟 번역 후 변형

unmodified

유전자 정보

bovine ... Dlg4(100137840)
mouse ... Dlg4(13385)
rat ... Dlg4(29495)

일반 설명

PSD-95 is part of a multiprotein complex restricted to the post-synaptic membrane. It is believed to initiate NMDA receptor clustering on the post synaptic membrane. Its restricted expression makes it an excellent marker for post-synaptic membrane regions on neurons.

특이성

Other species have not been tested.
Reacts with a protein of ~100 kDa, corresponding to the apparent molecular weight of PSD-95, on SDS-PAGE immunoblots of samples from rat, mouse and bovine. A slightly higher molecular weight band is also detected. In rat brain and mouse brain tissue extracts a band of ~75 kDa is also present.

면역원

Recombinant rat PSD-95.

애플리케이션

Anti-Post Synaptic Density Protein 95 Antibody, clone 6G6-1C9 detects level of Post Synaptic Density Protein 95 & has been published & validated for use in IC, IH & WB.
Immunocytochemistry:
Representative image from a previous lot.
Confocal fluorescent analysis of PC12 using MAb1596 Mouse mAB (Red). Actin filaments have been labeled with Alexa Fluor 488 -Phalloidin (Green). Nuclear is stained with DAPI (Blue). Membrane staining positive.

Immunocytochemistry:
12.5 µg/mL

Western Blot:
1-5 μg/mL (ECL) on rat brain lysate (20 μg).

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Synapse & Synaptic Biology

품질

Routinely evaluated in Immunocytochemistry.

표적 설명

~100 kDa

결합

Replaces: 04-1066

물리적 형태

Format: Purified
Purified immunoglobulin. Liquid in PBS, pH 7.2 with 50% glycerol and 0.09% sodium azide.
See datasheet for purification method.

저장 및 안정성

Stable for 6 months at -20°C in undiluted aliquots from date of receipt. Do not store below -20°C.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

분석 메모

Control
Mouse brain, rat brain tissue.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-induced silent damage.
Shi, L; Liu, L; He, T; Guo, X; Yu, Z; Yin, S; Wang, J
Testing null
Telencephalic neurons monosynaptically link brainstem and forebrain premotor networks necessary for song.
Roberts, TF; Klein, ME; Kubke, MF; Wild, JM; Mooney, R
The Journal of Neuroscience null
Pamela R Westmark et al.
Journal of visualized experiments : JoVE, (55)(55), doi:10-doi:10 (2011-09-29)
Synaptoneurosomes (SNs) are obtained after homogenization and fractionation of mouse brain cortex. They are resealed vesicles or isolated terminals that break away from axon terminals when the cortical tissue is homogenized. The SNs retain pre- and postsynaptic characteristics, which makes
Dongmei Zhang et al.
Synapse (New York, N.Y.), 64(11), 875-878 (2010-09-16)
Postsynaptic density protein-95 (PSD-95) is hypothesized to control the excitatory-to-inhibitory ratio and plays an important role in the regulation of hippocampal synaptic plasticity, synaptogenesis, and learning and memory. In this report, we used immunoblotting to study the effects of aging
Odile Poirel et al.
Scientific reports, 8(1), 938-938 (2018-01-19)
Synaptic loss, plaques and neurofibrillary tangles are viewed as hallmarks of Alzheimer's disease (AD). This study investigated synaptic markers in neocortical Brodmann area 9 (BA9) samples from 171 subjects with and without AD at different levels of cognitive impairment. The

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