추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
HP2/1, monoclonal
종 반응성
human, bovine, rat
제조업체/상표
Chemicon®
기술
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... ITGA4(3676)
rat ... Itga4(311144)
특이성
Recognizes the 80kDa alpha chain of VLA-4. Reacts with monocytes, T cells, B cells, thymocytes and Langerhans cells. Can be used in basic studies of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure. HP2/1 inhibits cell binding to soluble VCAM-1.
면역원
JM leukemia line
애플리케이션
Detect Integrin α4 using this Anti-Integrin α4 Antibody, clone HP2/1 validated for use in FC, IP, IH.
Flow cytometry: 1μg/5 X 10E5 cells
Immunohistology on frozen tissue sections
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Immunohistology on frozen tissue sections
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
결합
Replaces: 04-1131
물리적 형태
Format: Purified
Purified immunoglobulin - Ig fraction. Liquid in Phosphate Buffered Saline, pH 7.4 with 0.1% Sodium Azide.
저장 및 안정성
Store at -20°C in undiluted aliquots. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.
Weller, P F, et al.
Proceedings of the National Academy of Sciences of the USA, 88, 7430-7433 (1991)
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.
Hidenobu Kanda, Rebecca Newton, Russell Klein, Yuka Morita, Michael D Gunn, Steven D Rosen
Nature Immunology null
VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines.
Mattila, P, et al.
International Journal of Cancer. Journal International Du Cancer, 52, 918-923 (1992)
VLA-3: a novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization.
Sanchez-Madrid, F, et al.
European Journal of Immunology, 16, 1343-1349 (1986)
Jinah Park et al.
Oncogene, 23(19), 3474-3480 (2004-03-03)
Integrins are adhesion receptors that mediate both cell-extracellular matrix and cell-cell interactions. It has also been reported that the loss of integrin alpha4 expression might be associated with metastasis in several cancers. However, the molecular mechanism for loss of their
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