IL029

Interleukin-12 Protein, Recombinant human

The recombinant human Interleukin-12 protein (or IL-12 protein) is a potent regulator of cell mediated immune responses & it induces IFN-gamma production by NK & T cells.

• 동의어(들): IL-12
• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.77

속성

• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in CHO cells
• 분석: >98% (SDS-PAGE and HPLC)
• 특이 활성도: ≥1.0 x 10E6 U/mg
• 제조업체/상표: Chemicon^®
• 기술: cell culture | mammalian: suitable
• 불순물: <0.1 ng/μg endotoxin (of IL-12; 1EU/μg)
• 입력: sample type hematopoietic stem cell(s)
• UniProt 수납 번호: P29459; P29460
• 배송 상태: dry ice

설명

일반 설명

Interleukin-12 (IL-12) is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Human IL-12 is a disulfide linked heterodimeric protein with a molecular weight of 75 kDa comprised of disulfide-bonded 35 kDa (p35) and 40 kDa (p40) subunits.

Product Source: CHO cells (Chinese Hamster Ovarian cells)

애플리케이션

For most in vitro applications, IL-12 exerts its biological activity in the concentration range of 1.0 to 10.0 ng/mL.

생화학적/생리학적 작용

The ED50 as determined by the induction of IFN-g production from NK cells co-stimulated with IL-18 was ≤ 1.0 ng/mL

물리적 형태

The sterile filtered solution was lyophilized from 0.5X PBS pH 7.2

저장 및 안정성

The lyophilized IL-12, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 0.2 mg/mL. Reconstituted IL-12 should be stored in undiluted aliquots at -20°C for up to 6 months.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3