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Merck
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Key Documents

HSP1MAG-63K

Millipore

MILLIPLEX® Human Sepsis Magnetic Bead Panel 1 - Immune Response Multiplex Assay

Inflammation/Immunology Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple sepsis biomarkers in human serum, plasma and cell culture samples.

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About This Item

UNSPSC 코드:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Quality Level

종 반응성

human

제조업체/상표

Milliplex®

assay range

accuracy: 111%
(sVCAM-1)

accuracy: 114%
(MIF)

accuracy: 98%
(sFas)

standard curve range: 12-50,000 pg/mL
(sFas, sFasL, and PAI-1)

standard curve range: 61-250,000 pg/mL
(sVCAM-1 and sICAM-1)

기술

multiplexing: suitable

검출 방법

fluorometric (Luminex xMAP)

배송 상태

wet ice

일반 설명

Sepsis or SIRS (systemic inflammatory response syndrome) results from infection, whether bacterial, viral, fungal, or parasitic. According to the CDC, sepsis is the second leading cause of death in non-coronary ICU patients in the U.S. The pathogenesis of sepsis is very complex. Both an innate and acquired immune response to infection interrupts homeostasis with a shift of cytokine expression that increases immunosuppression. In addition, migration of the leukocytes in the inflamed tissues secretes a tissue factor leading to the formation of thrombin, also triggering the release of chemokines and adhesion molecules through endothelial cells. Severe sepsis occurs when hypotension or hypoperfusion to one or more organs leads to organ dysfunction, which, in turn, can cause septic shock, multiple organ dysfunction syndrome (MODS) and death.

MILLIPLEX® Human Sepsis Panel 1 is to be used for the simultaneous quantification of any or all of the following analytes in human serum, plasma and cell / tissue culture supernatant samples: sFAS/TNFRSF6, sFasL, sICAM-1, MIF, PAI-1 (total), sVCAM-1. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Immune Response

애플리케이션

  • Analytes: MIF, PAI-1 (Total), sFas, sFasL, sICAM-1, sVCAM-1
  • Recommended Sample type: Serum, plasma, tissue culture, or homogenates
  • Recommended Sample dilution: 1:10 for serum/plasma
  • Assay Run Time: Overnight
  • Research Category: Inflammation & Immunology

특징 및 장점

Design your multiplex kit by choosing available analytes within this panel.

기타 정보

Sensitivity: Refer to kit protocol for individual sensitivities.
Standard Curve Range: Refer to QC analysis sheet for exact concentration (MIF).

법적 정보

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

픽토그램

Exclamation markEnvironment

신호어

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

10 - Combustible liquids


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Dai Kimura et al.
Frontiers in pediatrics, 4, 31-31 (2016-04-12)
Lung injury activates multiple pro-inflammatory pathways, including neutrophils, epithelial, and endothelial injury, and coagulation factors leading to acute respiratory distress syndrome (ARDS). Low-dose methylprednisolone therapy (MPT) improved oxygenation and ventilation in early pediatric ARDS without altering duration of mechanical ventilation
Miša Korva et al.
Viruses, 11(8) (2019-07-31)
Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fever orthonairovirus can vary from a mild, nonspecific febrile

관련 콘텐츠

Immunology multiplex assays, like MILLIPLEX® assays, allow researchers to investigate more immune biomarkers simultaneously, saving time and resources. This is especially critical to immunology research, where numerous analytes play a role in different pathways.

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