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Merck
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Key Documents

AP130P

Sigma-Aldrich

Goat Anti-Mouse IgG & IgM Antibody, HRP conjugate

0.8 mg/mL, Chemicon®

동의어(들):

Goat Anti-Mouse IgG Antibody

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.46

생물학적 소스

goat

Quality Level

결합

peroxidase conjugate

항체 형태

F(ab′)2 fragment of affinity isolated antibody

항체 생산 유형

secondary antibodies

클론

polyclonal

종 반응성

mouse

제조업체/상표

Chemicon®

농도

0.8 mg/mL

기술

ELISA: suitable
western blot: suitable

배송 상태

wet ice

타겟 번역 후 변형

unmodified

관련 카테고리

일반 설명

Immunoglobulin G (IgG) is the most abundant immunoglobulin in the human serum. IgM constitutes 5-10% of total serum immunoglobulins. These immunoglobulins comprise four polypeptide chains with two heavy (H) chains and two light (L) chains. These polypeptide chains are inter-linked by disulfide bonds. IgM is a highly conserved antibody in vertebrates. IgM exists as a pentamer. Both IgG and IgM are secreted by B cells.

애플리케이션

Goat Anti-Mouse IgG & IgM Antibody, HRP conjugate has been used in western blotting(1:400) and immunofluorescence (1:500)

생화학적/생리학적 작용

IgG facilitates antibody-dependent cell-mediated cytotoxicity (ADCC). It also aids in the activation of the classical pathway of the complement system. IgG neutralizes virus particles and toxins. IgM, an antibody that is expressed early during an immune response, aids in engulfing apoptotic cells. It exhibits polyreactive and autoreactive functionality. IgM induces tissue homeostasis by mediating the clearance of tissue-based molecules. Lower levels of IgM in serum are associated with increased autoimmune response and a higher risk of developing infections.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Hongsheng Wang et al.
Frontiers in immunology, 7, 99-99 (2016-03-26)
Most natural IgM antibodies are encoded by germline Ig sequences and are produced in large quantities by both mice and humans in the absence of intentional immunization. Natural IgM are reactive with many conserved epitopes, including those shared by microorganisms
Chun-Shan Han et al.
Experimental and therapeutic medicine, 14(1), 181-186 (2017-07-05)
The present study investigated the effect of rutin on high glucose-induced actin, α2, smooth muscle, aorta (ACTA2) and p38 protein expression in diabetic nephropathy (DN). Human mesangial cells were divided into a control group, high glucose-induced mesangial cell group, high
Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy.
Hartnett, ME; Martiniuk, DJ; Saito, Y; Geisen, P; Peterson, LJ; McColm, JR
Investigative Ophthalmology & Visual Science null
Nelson K Chepkwony et al.
iScience, 24(9), 103071-103071 (2021-09-28)
Differences in ionic strength, pH, temperature, shear forces, and other environmental factors impact adhesion, and organisms have evolved various strategies to optimize their adhesins for their specific environmental conditions. Many species of Alphaproteobacteria, including members of the order Caulobacterales, use
Mari H Savolainen et al.
Neurobiology of disease, 68, 1-15 (2014-04-22)
The misfolding and aggregation of α-synuclein (aSyn) eventually lead to an accumulation of toxic forms that disturb normal neuronal function and result in cell death. aSyn rich inclusions are seen in Parkinson's disease, dementia with Lewy bodies and other synucleinopathies.

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