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Merck
모든 사진(5)

Key Documents

MAB302

Sigma-Aldrich

Anti-Glutamine Synthetase Antibody, clone GS-6

clone GS-6, Chemicon®, from mouse

동의어(들):

Anti-Glutamine

로그인조직 및 계약 가격 보기


About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

항체 형태

purified immunoglobulin

클론

GS-6, monoclonal

종 반응성

human, rat, mouse, sheep

제조업체/상표

Chemicon®

기술

ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

동형

IgG2a

NCBI 수납 번호

UniProt 수납 번호

배송 상태

dry ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... GLUL(2752)

일반 설명

Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. It is found in astrocytes as an octamer of identical 45 kDa subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer′s disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.

특이성

Reacts strongly with a single band on Western blots of sheep brain and rat brain. Glutamine synthetase, an enzyme that catalyzes the amination of glutamic acid to form glutamine, is found in mammals as an octamer of eight identical 45 kDa subunits. Glutamine synthetase activity has been shown to be a useful marker of astrocytes and an important differentiation feature in retina. Glutamine synthetase is also considered to be a key enzyme in the recycling of the neurotransmitter glutamate.

면역원

Glutamine synthetase purified from sheep brain.

애플리케이션

Detect Glutamine Synthetase using this Anti-Glutamine Synthetase Antibody, clone GS-6 validated for use in ELISA, IH, IH(P) & WB with more than 45 product citations.
Research Category
Neuroscience
Research Sub Category
Neurofilament & Neuron Metabolism
Western blot: 1:1,000-1:5,000

Immunohistochemistry on rat brain

ELISA

Optimal working dilutions must be determined by end user.

표적 설명

45 kDa

물리적 형태

Format: Purified
Protein A purified
Purified immunoglobulin. Liquid in buffer containing 50% glycerol, BSA and 0.09% sodium azide.

저장 및 안정성

Stable for 1 year at -20ºC in undiluted aliquots from date of receipt.

분석 메모

Control
Rat brain tissue, rat brain cytosolic fraction extract

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

N Hakuba et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(23), 8750-8753 (2000-01-11)
Acoustic overstimulation is one of the major causes of hearing loss. Glutamate is the most likely candidate neurotransmitter for afferent synapses in the peripheral auditory system, so it was proposed that glutamate excitotoxicity may be involved in noise trauma. However
H Ueda et al.
Investigative ophthalmology & visual science, 41(12), 3908-3914 (2000-10-29)
Dystrobrevin is a newly discovered dystrophin-associated protein with multiple sites for phosphorylation on tyrosine residues. In the present study, the cellular distribution and subcellular localization of dystrobrevin were examined in the adult rat retina, cornea, lens, iris, ciliary body, and
Alterations in protein expression and membrane properties during Muller cell gliosis in a murine model of transient retinal ischemia.
Hirrlinger PG, Ulbricht E, Iandiev I, Reichenbach A, Pannicke T
Neuroscience Letters null
Effects of retinal glial cells on isolated rat retinal ganglion cells.
K Kashiwagi, Y Iizuka, M Araie, Y Suzuki, S Tsukahara
Investigative Ophthalmology & Visual Science null
Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats.
Papageorgiou IE, Gabriel S, Fetani AF, Kann O, Heinemann U.
Glia null

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