추천 제품
생물학적 소스
human
Quality Level
분석
≤95% (SDS-PAGE)
형태
liquid
제조업체/상표
Chemicon®
농도
0.276 mg/mL
NCBI 수납 번호
UniProt 수납 번호
일반 설명
Apolipoprotein E (Apo E) is a multifunctional protein and exists in 3 isoforms namely apoE2, apoE3, and apoE4. It is the constituent of plasma lipoproteins. Apo E is produced by various tissues and is majorly found in interstitial fluid and lymph. It is released in a lipid-poor form.
애플리케이션
Apolipoprotein E, human has been used as a standard for the quantification of ApoE protein in the sucrose density gradient (SDG) fractions and the unfractionated brain homogenates using an in-house developed sandwich enzyme-linked immunosorbent assay (ELISA). It has also been used in western blotting to assess its exogenous effects on low-density lipoprotein (LDL)-heparin interactions.
생화학적/생리학적 작용
Apolipoprotein E (Apo E) serves as a ligand for low-density receptors and participates in the transport and redistribution of cholesterol and other lipids. It is thought to be involved in tissue repair as increased amounts of the protein are found at sites or peripheral nerve injury and regeneration. A mutant form is associated with type III hyperlipoproteinemia. Apo E plays a crucial role in neurobiology and neurodegenerative diseases.
물리적 형태
Liquid in 10 mM NH4HCO3, pH 8.0.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Yadong Huang et al.
Neurobiology of disease, 72 Pt A, 3-12 (2014-09-01)
Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3, and apoE4) with different effects on lipid and neuronal homeostasis. A major function of apoE is
Paul S Hauser et al.
Progress in lipid research, 50(1), 62-74 (2010-09-22)
Apolipoprotein (apo) E has a storied history as a lipid transport protein. The integral association between cholesterol homeostasis and lipoprotein clearance from circulation are intimately related to apoE's function as a ligand for cell-surface receptors of the low-density lipoprotein receptor
Zaili Yang et al.
Journal of virology, 90(21), 9632-9643 (2016-08-19)
Hepatitis C virus (HCV) is a major cause of chronic liver disease, infecting approximately 170 million people worldwide. HCV assembly is tightly associated with the lipoprotein pathway. Exchangeable apolipoprotein E (apoE) is incorporated on infectious HCV virions and is important
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