ABS528

Anti-S1P lyase Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): S1PL, SPL1, mSPL, Sphingosine-1-phosphate aldolase
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: mouse
• 기술: western blot: suitable
• NCBI 수납 번호: NP_033189
• UniProt 수납 번호: Q8R0X7
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Sgpl1(20397)

설명

일반 설명

S1P lyase is an important enzyme in lipid, steroid, and ceramide metabolism. S1P lyase 1 specifically cleaves phosphorylated sphingoid bases such as sphingosine-1-phosphate into fatty aldehydes and phosphoethanolamine. S1P lyase also plays roles in apoptosis with regards to regulation of ceramide production and plays roles in cell differentiation via its role in androgen and estrogen metabolism as well as that of other important lipids and bioactive lipid derivatives. S1P lyase is expressed in the endoplasmic reticulum in many cells. Interestingly, because Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning, its catabolism by S1P lyase is very important in recovery from heart attacks or other ischemia related events, and thus S1P lyase is being examined as a potential new therapeutic target for reperfusion therapy in heart disease.

면역원

Epitope: cytoplasmic domain

Linear peptide corresponding to the cytoplasmic domain of Mouse S1P lyase.

애플리케이션

Research Category
Signaling

Metabolism

Research Sub Category
Lipid Metabolism & Weight Regulation

Lipid Signaling

This Anti-S1P lyase Antibody is validated for use in Western Blotting for the detection of S1P lyase.

Western Blotting Analysis: A representative lot of this antibody detected S1P lyase in 30 μg of lysate from various mice tissues (Bektas, M., et al. (2010). Journal of Biological Chemistry Vol. 285, NO. 14, pp. 10880–10889)

품질

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected SP-lyase1 in 10 µg of mouse lung tissue lysate.

표적 설명

~ 56 kDa observed

물리적 형태

Antigen Affinity Purified

Purified rabbit polyclonal in buffer with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2