ABN1469

Anti-Alpha-2-HS-Glycoprotein

from rabbit, purified by affinity chromatography

• 동의어(들): Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A, Alpha-2 Heremans-Schmid glycoprotein, AHGS
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 클론: polyclonal
• application: IHC; WB
• 종 반응성: human
• 기술: immunohistochemistry: suitable; western blot: suitable

속성

• 생물학적 소스: rabbit
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 포장: antibody small pack of 25 μL
• 기술: immunohistochemistry: suitable; western blot: suitable
• NCBI 수납 번호: NP_001613.2
• UniProt 수납 번호: P02765
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... AHSG(197)

설명

일반 설명

Alpha-2-HS-glycoprotein (UniProt: P02765; also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A, Alpha-2 Heremans-Schmid glycoprotein, AHSG) is encoded by the AHSG (also known as FETUA, PRO2743) gene (Gene ID: 197) in human. Alpha-2-HS-glycoprotein is a serum protein of the cystatin superfamily that is synthesized by hepatocytes and is considered as a negative acute-phase reactant. It is highly expressed in various fetal tissues, but in adults it is mainly expressed in the liver. It is synthesized with a signal peptide (aa 1-18) and a connective propeptide (aa 301-340) and is subsequently cleaved into 2 chains known as Alpha-2-HS-glycoprotein chain A and Alpha-2-HS-glycoprotein chain B. The mature product is involved in multiple normal biological and pathological functions. It promotes possesses opsonic properties and is shown to be involved in endocytosis, brain development, bone resorption, regulation of insulin activity and hepatocyte growth factor (HGF) activity. Alpha-2-HS-glycoprotein also serves as a carrier protein and serves as a carrier for otherwise insoluble calcium phosphate and can act as a potent inhibitor of pathological vascular calcification. Higher levels of Alpha-2-HS-glycoprotein have been reported in gestational and type II diabetes. It is also present at higher levels in patients with endometriosis. Lower levels of Alpha-2-HS-glycoprotein are present in cancer subjects. (Ref.: Kalabay, L., et al. (2002). Eur. J. Endocrinol. 147(2); 243-248; Sindhu, S., et al. (2016). BMC Immunol. 17; 33).

특이성

This rabbit polyclonal antibody specifically detects human Alpha-2-HS-glycoprotein. It targets an epitope with in the N-terminal half.

면역원

Epitope: N-terminus

GST/His-tagged recombinant fragment corresponding to 146 amino acids from human Alpha-2-HS-glycoprotein.

애플리케이션

Anti-Alpha-2-HS-Glycoprotein Antibody, Cat. No. ABN1469, is a highly specific rabbit polyclonal antibody that targets Alpha-2-HS-Glycoprotein and has been tested for use Immunohistochemistry and Western Blotting.

Research Category
Neuroscience

Western Blotting Analysis: A 1:500 dilution from a representative lot detected Alpha-2-HS-Glycoprotein in human retina tissue lysate.

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Alpha-2-HS-Glycoprotein in human liver and human bone marrow tissue sections.

품질

Evaluated by Western Blotting in human serum.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Alpha-2-HS-Glycoprotein in human serum.

표적 설명

~55 kDa observed; 39.33 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

물리적 형태

Affinity Purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.