ABE1028

Anti-E3 ubiquitin-protein ligase UHRF2 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): E3 ubiquitin-protein ligase UHRF2, Np95/ICBP90-like RING finger protein, Np95-like RING finger protein, Nuclear protein 97, Nuclear zinc finger protein Np97, RING finger protein 107, Ubiquitin-like PHD and RING finger domain-containing protein 2, Ubiquit
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 기술: immunohistochemistry: suitable; western blot: suitable
• NCBI 수납 번호: NP_690856
• UniProt 수납 번호: Q96PU4
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... UHRF2(115426)

설명

일반 설명

UHRF2 plays a critical role in cell cycle as it ubiquitinates cyclins and induces G1 arrest. UHRF2 also participates in epigenetic control of gene expression in many cells through binding and ubiquitinating DNA and histone binding proteins and targeting them for degradation. UHRF2 binds methylated CpG containing oligonucleotides as well and interacts directly with histone H3 as well as the trimethylated form of H3. UHRF2 is also recruited to areas of DNA damage and is important for DNA stability. UHRF2 is localized in the nucleus in heterochromatin. UHRF2 up regulated expression is associated with various cancers, however typically as mutated or lower copy number forms, which appear to has impaired anti-proliferation abilities.

면역원

Epitope: Region required for interaction with histone H3 and interaction with PCNP

KLH-conjugated linear peptide corresponding to the region required for interaction with histone H3 and interaction with PCNP of human E3 ubiquitin-protein ligase UHRF2.

애플리케이션

Anti-E3 ubiquitin-protein ligase UHRF2 Antibody is an antibody against E3 ubiquitin-protein ligase UHRF2 for use in Immunohistochemistry and Immunocytochemistry.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected E3 ubiquitin-protein ligase UHRF2 in human testis and human kidney tissue.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Nuclear Receptors

품질

Evaluated by Western Blotting in WI-38 cell lysate.

Western Blotting Analysis: A 1:5,000 dilution of this antibody detected E3 ubiquitin-protein ligase UHRF2 in 10 µg of WI-38 cell lysate.

표적 설명

~58 kDa observed

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable