AB5840-I

Anti-Dab1

from rabbit

• 동의어(들): Disabled homolog 1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 클론: polyclonal
• application: IHC; WB
• 종 반응성: mouse
• 기술: immunohistochemistry: suitable (paraffin); western blot: suitable
• citations: 1

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 종 반응성: mouse
• 포장: antibody small pack of 25 μg
• 기술: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI 수납 번호: NP_796233
• UniProt 수납 번호: P97318
• 배송 상태: ambient
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Dab1(13131)

설명

일반 설명

Disabled homolog 1 (UniProt: P97318; also known as DAB1) is encoded by the Dab1 gene (Gene ID: 13131) in murine species. Dab 1 is mainly expressed in the brain and serves as an adapter molecule involved in neural development where it is reported to direct the migration of cortical neurons past previously formed neurons to reach their proper layer. DAB1 is can be phosphorylated on Tyr198, Tyr220, and Tyr232 upon reelin induction in embryonic neurons. It can also be phosphorylated on Ser524, but this phosphorylation is independent of reelin signaling. Tyrosine phosphorylation of DAB1 by Src family tyrosine kinases is considered to be the most critical downstream event in Reelin signaling. DAB1 contains a phosphotyrosine interaction domain (PID) (aa 36-189), which specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins. Seven different isoforms of Dab1 have been identified that are generated via alternative splicing.

특이성

This rabbit polyclonal antibody detects murine Disabled homolog 1 (Dab1). It targets an epitope within 156 amino acids from the C-terminal half.

면역원

GST-tagged recombinant fragment corresponding to 156 amino acids from the C-terminal half of murine Disabled homolog 1 (Dab1).

애플리케이션

Anti-Dab1, Cat. No. AB5840-I, is a highly specific rabbit polyclonal antibody that targets Disabled homolog 1 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Dab1 in mouse cerebral cortex tissue sections.

Research Category
Neuroscience

품질

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected Dab1 in 10 µg of mouse brain tissue lysate.

표적 설명

~64 kDa observed; 63.58 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

물리적 형태

Affinity Purified

Format: Purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.