추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
serum
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
hamster, human, mouse, monkey
제조업체/상표
Chemicon®
기술
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... PSEN1(5663)
특이성
Presenilin-1, Loop.
면역원
Epitope: loop, a.a. 275-367, C-terminus
Human Presenilin-1 (amino acids 275-367) fused to C-terminus of maltose binding protein.
애플리케이션
Anti-Presenilin-1 Antibody, loop, a.a. 275-367, C-terminus is an antibody against Presenilin-1 for use in IP, WB & IC.
Immunocytochemistry: Cos7, SY5Y cell lines.
Western blot: 1:500-1:3000
Immunoprecipitation.
Optimal working dilutions must be determined by end user.
Western blot: 1:500-1:3000
Immunoprecipitation.
Optimal working dilutions must be determined by end user.
물리적 형태
Rabbit serum. Liquid in PBS with 0.01% sodium azide.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1.
Chen, Y; Bodles, AM; McPhie, DL; Neve, RL; Mrak, RE; Griffin, WS
Mol. Neurodegener. null
Presenilin-1 and its N-terminal and C-terminal fragments are transported in the sciatic nerve of rat.
P Kasa, H Papp, M Pakaski
Brain Research null
Anna Bergman et al.
The Journal of biological chemistry, 279(44), 45564-45572 (2004-08-24)
The gamma-secretase complex catalyzes the cleavage of the amyloid precursor protein in its transmembrane domain resulting in the formation of the amyloid beta-peptide and the cytoplasmic APP intracellular domain. The active gamma-secretase complex is composed of at least four subunits:
Arnaldo Parra-Damas et al.
Scientific reports, 7(1), 18004-18004 (2017-12-23)
Gene expression mediated by the transcription factor cAMP-responsive element-binding protein (CREB) is essential for a wide range of brain processes. The transcriptional coactivartor CREB-regulated transcription coactivator-1 (CRTC1) is required for efficient induction of CREB target genes during neuronal activity. However, the mechanisms regulating induction of specific CREB/CRTC1-dependent
Marcella M Authiat et al.
Neural plasticity, 2022, 3172861-3172861 (2022-03-04)
Recently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ 42-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs in cells and murine
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