AB15080

Anti-Frataxin Antibody

from rabbit

• 동의어(들): Anti-CyaY, Anti-FA, Anti-FARR, Anti-FRDA, Anti-X25
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 종 반응성: rat, mouse, human
• 기술: western blot: suitable
• NCBI 수납 번호: NP_000135
• UniProt 수납 번호: Q16595
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... FXN(2395) ; mouse ... Fxn(14297) ; rat ... Fxn(499335)

설명

일반 설명

Frataxin is a nuclear encoded protein that is found in the mitochondria. This protein is not well understood but may be involved with iron sulfur clusters. In humans the gene is localized on chromosome 9 and is highly conserved during evolution. The gene is expressed in every cell, although in varying levels in different tissues and during development. The specific function of Frataxin is still unknown, but it has been shown to play a role in iron metabolism. Studies have demonstrated that the deletion of the Frataxin gene in yeast results in iron accumulation in mitochondria and loss of respiration. Recombinant human Frataxin has been shown to bind iron in vitro, and increased mitochondrial iron levels have been observed in patients with Friedreich′s Ataxia (FRDA).

특이성

Cat. # AB15080 recognizes Frataxin.

면역원

Epitope: mature chain

GST-tagged Frataxin corresponding to mature chain.

애플리케이션

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

This Anti-Frataxin Antibody is validated for use in WB for the detection of Frataxin.

품질

Routinely evaluated by Western Blot on Human heart lysates.

Western Blot Analysis: 1:1,000 - 1:10,000 dilution of this lot detected Frataxin on 10 ug of human heart lysate

표적 설명

Approx. 18 kDa

물리적 형태

Format: Purified

GST-depleted sera

Rabbit polyclonal serum in buffer containing 0.05% NaN3.

저장 및 안정성

Stable for 1 year at -20ºC from date of receipt.

분석 메모

Control
Human heart lysate.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable