추천 제품
Quality Level
제품 라인
Novabiochem®
형태
beads
반응 적합성
reaction type: Fmoc solid-phase peptide synthesis
제조업체/상표
Novabiochem®
응용 분야
peptide synthesis
작용기
amine
저장 온도
2-8°C
일반 설명
An acid-labile resin for the preparation of N-acyl or N-alkyl cysteamines. The free amino functionality of the resin-bound cysteamine can be readily acylated or reductively alkylated using standard procedures. Cleavage can be effected with electrophilic oxidants such as I2 or Tl(3) to produce a dimeric disulfide bridged product, or with 50-100% TFA to give the monomeric sulfhydryl product. Peptidylaminoethylthiols produced in this manner have been used to prepare PEG-conjugates by chemoselective ligation to pegylated maleimide [1]. This method is particularly useful for forming intramolecular disulfide bridges in molecules containing two thiol groups where one is protected with Acm. For a similar application, see [2,3,4].
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] J. Zhang, et al. Poster 162 presented at the 16 American Peptide Symposium, Minneapolis, 1999.
[2] A. v. Vliet, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium′, R. Epton (Eds), Intercept UK Ltd., Andover, 1992, pp. 475.
[3] A. v. Vliet, et al. in ′Peptides 1992, Proc.22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 279.
[4] A. v. Vliet, et al. in ′Peptides, Chemistry, Structure, &Biology, Proc. 13th American Peptide Symposium′, R. S. Hodges & J. A. Smith (Eds), ESCOM, Leiden, 1994, pp. 151.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] J. Zhang, et al. Poster 162 presented at the 16 American Peptide Symposium, Minneapolis, 1999.
[2] A. v. Vliet, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium′, R. Epton (Eds), Intercept UK Ltd., Andover, 1992, pp. 475.
[3] A. v. Vliet, et al. in ′Peptides 1992, Proc.22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 279.
[4] A. v. Vliet, et al. in ′Peptides, Chemistry, Structure, &Biology, Proc. 13th American Peptide Symposium′, R. S. Hodges & J. A. Smith (Eds), ESCOM, Leiden, 1994, pp. 151.
결합
Replaces: 01-64-0107
분석 메모
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 1.00 - 2.00 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1% DVB), 200 - 400 mesh.
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 1.00 - 2.00 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1% DVB), 200 - 400 mesh.
법적 정보
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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