574713

Syk Inhibitor III

The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): Syk Inhibitor III, 3,4-Methylenedioxy-β-nitrostyrene
• 실험식(Hill 표기법): C₉H₇NO₄
• CAS Number: 1485-00-3
• Molecular Weight: 193.16
• MDL number: MFCD00014575
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (GC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow to brown
• solubility: DMSO: 25 mg/mL (Use only fresh DMSO.)
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-
• InChI key: KFLWBZPSJQPRDD-ARJAWSKDSA-N

설명

일반 설명

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC₅₀ = 2.5 µM). It inhibits Src only at much higher concentrations (IC₅₀ = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC₅₀ ranges from 2.1 to 25.9 µM).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Syk

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2.5 µM against Syk kinase activity

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315 - H319
• 예방조치 성명서: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3