567732

Sphingosine Kinase 1 Inhibitor, SKI-178

• 동의어(들): Sphingosine Kinase 1 Inhibitor, SKI-178, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
• 실험식(Hill 표기법): C₂₁H₂₂N₄O₄
• Molecular Weight: 394.42
• UNSPSC 코드: 12352200
• NACRES: NA.28

속성

• 분석: ≥92% (HPLC)
• Quality Level: 100
• 형태: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 100 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (K_i = 1.33 and >>25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC₅₀ in the range of 0.1-1.8 µM).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett.20, 7498

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable