567022

Simvastatin sodium salt

≥95% (HPLC), liquid, L-type calcium channel blocker, Calbiochem^®

• 동의어(들): InSolution Simvastatin, Sodium Salt, L-Type Calcium Channel Blocker VI
• 실험식(Hill 표기법): C₂₅H₃₉O₆ · Na
• Molecular Weight: 458.56
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• 제품명: Simvastatin, Sodium Salt, InSolution, ≥95%
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 배송 상태: ambient
• 저장 온도: −70°C

설명

일반 설명

Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca²⁺-signaling and insulin secretion by blocking L-type Ca²⁺ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available.

생화학적/생리학적 작용

Cell permeable: yes

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

물리적 형태

A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H₂O.

재구성

Following initial thaw, aliquot and freeze (-70°C).

기타 정보

Yada, T., et al. 1999. Br. J. Pharmacol.126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol.102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol.94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int.52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable