추천 제품
Quality Level
분석
≥95% (HPLC)
양식
liquid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
desiccated (hygroscopic)
protect from light
배송 상태
wet ice
저장 온도
2-8°C
일반 설명
A potent and selective inhibitor of cyclin-dependent kinases (Cdks). Exhibits greater inhibitory potency compared to olomoucine (Cat. No. 495620). Inhibits p34 Cdc2/cyclin B (IC50 = 650 nM), p33 Cdk2/cyclin A (IC50 = 700 nM), p33 Cdk2/cyclin E (IC50 = 700 nM), and p33 Cdk2/p35 (IC50 = 200 nM) by competing for the ATP binding domain of these kinases. Exhibits very low sensitivity towards related kinases, such as Erk1 and Erk2 (IC50 = 34 µM and 14 µM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 µM and compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle.
생화학적/생리학적 작용
Cell permeable: no
Primary Target
p34cdk1/cyclin B
p34cdk1/cyclin B
Product competes with ATP.
Reversible: yes
Target IC50: 650 nM, 700 nM, 700 nM, and 200 nM against p34cdk1/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, and p33cdk5/p35, respectively
포장
Packaged under inert gas
경고
Toxicity: Irritant (B)
물리적 형태
A 50 mM (5 mg/282 µl) solution of Roscovitine (Cat. No. 557360) in DMSO.
재구성
Following initial use, aliquot and freeze (-20°C). Once opened, the DMSO aliquots are stable for up to 6 months at -20°C.
기타 정보
Meijer, L. 1996. Trends Cell Biol.6, 393.
Rudolph, B., et al. 1996. EMBO J.15, 3053.
Rudolph, B., et al. 1996. EMBO J.15, 3053.
법적 정보
Sold under license of U.S. Patent 6,316,456.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Flash Point (°C)
87 °C - closed cup - (Dimethylsulfoxide)
시험 성적서(COA)
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