539749

PTP1B Inhibitor

InSolution, ≥97%

• 동의어(들): InSolution PTP1B Inhibitor, PTP Inhibitor XXII
• 실험식(Hill 표기법): C₂₆H₁₉Br₂N₃O₇S₃
• Molecular Weight: 741.45
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B₄₀₃ and PTP1B₂₉₈, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.

생화학적/생리학적 작용

Cell permeable: yes

IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

물리적 형태

A 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.

재구성

Following initial thaw, aliquot and freeze (-20°C).

기타 정보

Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Flash Point (°C): 87 °C - closed cup - (Dimethylsulfoxide)