530050-M

PRIMA-1

A cell-permeable quinuclidinone analog with antitumor properties.

• 동의어(들): PRIMA-1, 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
• 실험식(Hill 표기법): C₉H₁₅NO₃
• CAS Number: 5608-24-2
• Molecular Weight: 185.22
• MDL number: MFCD04974196
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (NMR)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: off-white
• solubility: water: 2 mg/mL
• 저장 온도: 2-8°C
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• InChI key: RFBVBRVVOPAAFS-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.

A cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.

생화학적/생리학적 작용

Primary Target
Restores biochemical and biological function to mutant p53

경고

Toxicity: Standard Handling (A)

기타 정보

Bykov, V.J., et al. 2002. Nat. Med.8, 282.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H334
• 예방조치 성명서: P261 - P264 - P270 - P284 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable