528110-M

PIH

A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class.

• 동의어(들): PIH, pyridoxal isonicotinoyl hydrazone, Iron Chelator III
• 실험식(Hill 표기법): C₁₄H₁₄N₄O₃
• CAS Number: 737-86-0
• Molecular Weight: 286.29
• UNSPSC 코드: 12352200
• NACRES: NA.28

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 양식: solid
• 반응 적합성: reagent type: chelator
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: DMSO: 5 mg/mL; slighlty acidic medium: soluble
• 저장 온도: 2-8°C
• InChI: 1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,17,19H,8H2,1H3,(H,18,21)/b12-7+
• InChI key: HOYFGBFEIXEDEL-KPKJPENVSA-N

설명

일반 설명

A cell-permeable, non-toxic tridendate iron (Fe³⁺) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe³⁺ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity.

A cell-permeable, non-toxic, iron (Fe³⁺) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe³⁺ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Desferrioxamine (Cat. No. 252750) but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity.

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.

기타 정보

Buss, J.L., et al. 2002. Biochem. Pharmacol.64, 1689.
Thomas, S.R., et al. 2001. J. Immunol.166, 6332.
Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta1523, 154.
Blaha, K., et al. 1998. Blood11, 4368.
Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med.131, 306.
Richardson, D.R.,et al. 1995. Blood86, 4295.
Richardson, D.R., et al. 1994. J. Lab. Clin. Med.124, 660.
Ponka, P., et al. 1988. Biochim. Biophys. Acta967, 122.
Ponka, P., et al. 1984. Biochim. Biophys. Acta802, 477.
Ponka, P., et al. 1979. FEBS Lett.97, 317.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable