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Merck
모든 사진(1)

주요 문서

5.09374

Sigma-Aldrich

L524-0366

≥98% (HPLC), powder, Fn14 antagonist, Calbiochem®

동의어(들):

Fn14 Antagonist, L524-0366, Fibroblast Growth Factor-inducible 14 Antagonist; L5240366, THD Receptor Antagonist; TNF-like Weak Inducer of Apoptosis Receptor Antagonist, TWEAK Receptor Antagonist; TWEAK-Fn14 Interaction Inhibitor

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C13H13ClN4OS
CAS Number:
951612-19-4
Molecular Weight:
308.79
MDL number:
MFCD15129559
UNSPSC 코드:
12352200
PubChem Substance ID:
20973801
NACRES:
NA.77

제품명

Fn14 Antagonist, L524-0366,

분석

≥98% (HPLC)

Quality Level

100

양식

powder

효능

7.12 μM Ki

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
protect from light

색상

white

solubility

DMSO: 25 mg/mL

저장 온도

2-8°C

SMILES string

C1CSCCN1C(=O)C2=CN(N=N2)C3=CC(=CC=C3)Cl

InChI

1S/C13H13ClN4OS/c14-10-2-1-3-11(8-10)18-9-12(15-16-18)13(19)17-4-6-20-7-5-17/h1-3,8-9H,4-7H2

InChI key

ZOBDTKWDYMRKPF-UHFFFAOYSA-N

일반 설명

A triazolyl-thiomorpholinyl-methanone compound that acts as a fibroblast growth factor-inducible 14 (Fn14) antagonist via direct affinity interaction (KD = 7.12 µM) and competes against TNF-like Weak Inducer of Apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (16.8% inhibition against 500 pg/mL sTWEAK; [Drug] = 25 µM). Shown to completely inhibit 100 ng/mL sTWEAK-stimulated migration of T98G glioma cells at 10 µM concentration and is more potent against sTWEAK- than TNFα-induced NF-κB activation (IC50 = 7.8 vs. 31.03 µM, respectively, in reporter assays using Fn14-NF-kB-Luc and NF-κB-Luc cells) without any apparent cytotoxicity up to 50 µM and 72 h in T98G cultures.

생화학적/생리학적 작용

Primary Target
fibroblast growth factor-inducible 14 (Fn14)
Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Use only fresh DMSO for reconstitution.

기타 정보

Dhruv, H., et al. 2013. J. Biol. Chem.288, 32261.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Harshil Dhruv et al.
The Journal of biological chemistry, 288(45), 32261-32276 (2013-09-24)
Deregulation of the TNF-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling pathway is observed in many diseases, including inflammation, autoimmune diseases, and cancer. Activation of Fn14 signaling by TWEAK binding triggers cell invasion and survival and therefore

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