5.08438

Lamellipodial Growth Promoter, C8N6 BPA Polyamine

• 동의어(들): Lamellipodial Growth Promoter, C8N6 BPA Polyamine, Actin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
• 실험식(Hill 표기법): C₂₀H₄₈N₆ · 6HCl
• CAS Number: 870087-09-5
• Molecular Weight: 591.40
• MDL number: MFCD00048297
• UNSPSC 코드: 12352116
• NACRES: NA.77

속성

• 분석: ≥95% (NMR)
• Quality Level: 100
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: water: 100 mg/mL; DMSO: 50 mg/mL
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

생화학적/생리학적 작용

Cell permeable: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Nedeva, I., et al. 2013. Nat. Commun.4, 2165.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable