5.06188

Sertraline Hydrochloride

• 동의어(들): Sertraline Hydrochloride, Serotonin (5-HT) Reuptake Inhibitor, Sertraline, Zoloft
• 실험식(Hill 표기법): C₁₇H₁₇Cl₂N · xHCl
• CAS Number: 79559-97-0
• Molecular Weight: 306.23 (free base basis)
• MDL number: MFCD00895772
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥99% (HPLC)
• Quality Level: 100
• 양식: solid
• 효능: 3.3 nM K_i
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 100 mM; ethanol: 50 mM
• 저장 온도: 2-8°C
• SMILES string: [Cl-].Clc1c(ccc(c1)[C@@H]2CC[C@@H](c3c2cccc3)[N+H2]C)Cl
• InChI: 1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
• InChI key: BLFQGGGGFNSJKA-XHXSRVRCSA-N

설명

일반 설명

A very potent uptake inhibitor highly selective for serotonin (K_i = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.

생화학적/생리학적 작용

Primary Target
5-HT uptake transporter

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.

Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07,GHS08,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302 - H373 - H410
• 예방조치 성명서: P260 - P264 - P273 - P301 + P312 - P314 - P391
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable