506181

p75^NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5

The p75^NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 controls the biological activity of p75^NTR. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 동의어(들): p75^NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, TAT-Pep5, H- YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
• 실험식(Hill 표기법): C₁₅₀H₂₂₇N₅₇O₃₂S₂
• Molecular Weight: 3404.90
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

The p75^NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

H₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH

disulfide bond (12-26)

물리적 형태

Supplied as a trifluoroacetate salt.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci.6, 461.
Schwarze, S.R., et al. 1999. Science285, 1569.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable