5.06046

PRMT Inhibitor VII, DB867

• 동의어(들): PRMT Inhibitor VII, DB867, 5-[5-(4-Carbamimidoyl-phenyl)-furan-2-yl]-pyridine-2-carboxamidine
• 실험식(Hill 표기법): C₁₇H₁₅NO₅
• CAS Number: 619334-60-0
• Molecular Weight: 313.30
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: solid
• 효능: 9 μM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: 10% acetic acid: 5 mg/mL
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC₅₀ = 110 µM) and PRMT6 (IC₅₀ = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC₅₀ = 110 µM) and PRMT6 (IC₅₀ = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

생화학적/생리학적 작용

Primary Target
PRMT1

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Xu, J., et al, 2013. Mol. Cell.51, 1.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable