5.05986

SR 95531

≥98% (HPLC), solid, GABAA receptor antagonist, Calbiochem^®

• 동의어(들): SR95531 (Gabazine), GABA _A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531, GABA_A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531
• 실험식(Hill 표기법): C₁₅H₁₇N₃O₃ · xHBr
• CAS Number: 104104-50-9
• Molecular Weight: 287.31 (free base basis)
• MDL number: MFCD00055135
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: SR95531 (Gabazine),
• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: solid
• 효능: 440 nM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: water: 25 mM
• 저장 온도: 2-8°C
• InChI: 1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H
• InChI key: GFZHNFOGCMEYTA-UHFFFAOYSA-N

설명

일반 설명

A selective, competitive antagonist of GABA_A receptor (IC₅₀ = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µM). Also shown to block glycine receptors, but with low affinity (K_b = 190 µM).

A selective, competitive antagonist of GABA_A receptor (IC₅₀ = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 mM). Also shown to block glycine receptors, but with low affinity (K_b = 190 mM).

생화학적/생리학적 작용

Primary Target
GABA_A

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Muroi, Y., et al. 2009. Biophys. J.96, 499.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable