5.04844

7-Chlorokynurenic Acid Sodium Salt

• 동의어(들): 7-Chlorokynurenic Acid Sodium Salt, 7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
• 실험식(Hill 표기법): C₁₀H₅ClNNaO₃
• CAS Number: 1263094-00-3
• Molecular Weight: 245.59
• UNSPSC 코드: 12352106
• NACRES: NA.77

속성

• 분석: ≥99% (HPLC)
• Quality Level: 100
• 양식: solid
• 효능: 0.56 μM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: water: 100 mM
• 저장 온도: 2-8°C
• InChI: 1S/C10H6ClNO3.Na/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13;/h1-4H,(H,12,13)(H,14,15);/q;+1/p-1
• InChI key: IFZYIORLNGNLEI-UHFFFAOYSA-M

설명

일반 설명

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC₅₀ = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.

생화학적/생리학적 작용

Primary Target
NMDA receptors

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Kemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A.85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol.280, 37.
Bartlett, D., et al. 1999. Neuropharmacol.37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol.199, 32.
Stone, W., et al. 2012. FEBS J.279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc.12, 64.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable