481412

NF-kB Activation Inhibitor IV

The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 동의어(들): NF-kB Activation Inhibitor IV, (E)-2-Fluoro-4ʹ-methoxystilbene
• 실험식(Hill 표기법): C₁₅H₁₃FO
• CAS Number: 139141-12-1
• Molecular Weight: 228.26
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: crystalline solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• solubility: DMSO: 20 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC₅₀ = 150 nM).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
NF-κB Activation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Heynekamp, J.J., et al. 2006. J. Med. Chem.49, 7182.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable