475882-M

ML-9, Hydrochloride

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM).

• 동의어(들): ML-9, Hydrochloride, 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl
• 실험식(Hill 표기법): C₁₅H₁₇ClN₂O₂S · xHCl
• CAS Number: 105637-50-1
• Molecular Weight: 324.83 (free base basis)
• MDL number: MFCD00065525
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (TLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: 50% ethanol: 10 mg/mL
• 저장 온도: 2-8°C
• InChI: 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
• InChI key: ZNRYCIVTNLZOGI-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.

생화학적/생리학적 작용

Primary Target
Mlck

Target K_i: 3.8 µM, 32 µM, 54 µM against myosin light chain kinase, protein kinase A, and protein kinase C, respectively

경고

Toxicity: Standard Handling (A)

제조 메모

Further dilute with aqueous buffer just prior to use.

재구성

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

기타 정보

Reig, J.A., et al. 1993. Neurochem. Res. 18, 317.
Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun.143, 1045.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun.140, 280.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable