426205

β-Lactamase, Bacillus cereus 569/H9

• 동의어(들): β-Lactamase, Bacillus cereus 569/H9, Penicillinase
• CAS Number: 9073-60-3
• 효소 위원회 번호: 3.5.2.6 (BRENDA, IUBMB)
• MDL number: MFCD00131819
• UNSPSC 코드: 12352202
• NACRES: NA.54

속성

• 생물학적 소스: Bacillus sp. (Bacillus cereus)
• Quality Level: 100
• 형태: lyophilized
• 포장: vial of ≥50 units β-lactamase II; vial of ≥500 units β-lactamase I
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• solubility: sterile distilled water: soluble
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

β-Lactamase produced by bacteria shares sequence homology to penicillin-binding proteins. This enzyme is found in Gram-negative bacteria. β-Lactamases have four molecular classes, named A, B, C, and D. A, C, and D form an acyl-enzyme via active site serine residue. Class B β-lactamases are metalloenzymes, which have a zinc ion at their active site for β-lactam hydrolysis.

생화학적/생리학적 작용

β-Lactamase hydrolyzes β-lactum antibiotics and is the chief cause of resistance to β-lactam antibiotics development by bacteria. Mutations in the β-lactamases are associated with extended-spectrum β-lactamases (ESBLs).

경고

Toxicity: Harmful (C)

단위 정의

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol benzyl penicillin and 1.0 µmol of cephalosporin C, respectively, per min at 25°C.

재구성

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H317,H334
• 예방조치 성명서: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable