420600

Ketoconazole

An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities.

• 동의어(들): Ketoconazole, cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
• 실험식(Hill 표기법): C₂₆H₂₈Cl₂N₄O₄
• CAS Number: 65277-42-1
• Molecular Weight: 531.43
• MDL number: MFCD00058579
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 효능: 26 μM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: off-white
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
• InChI key: XMAYWYJOQHXEEK-ZEQKJWHPSA-N

설명

일반 설명

An inhibitor of cytochrome P-450 in steroid biosynthesis. An anti-fungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC₅₀ = 26 µM) and thromboxane synthase activities.

An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC₅₀ = 26 µM) and thromboxane synthase activities.

생화학적/생리학적 작용

Primary Target
5-LO

경고

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

van Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
Lelcuk, S., et al. 1984. J. Trauma 24, 393.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06,GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H301,H360F,H373,H410
• 예방조치 성명서: P202 - P260 - P264 - P273 - P280 - P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - STOT RE 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable