382110

Histone Acetyltransferase Inhibitor II

The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 동의어(들): Histone Acetyltransferase Inhibitor II, 2,6- bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I, 2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I
• 실험식(Hill 표기법): C₂₀H₁₆Br₂O₃
• CAS Number: 932749-62-7
• Molecular Weight: 464.15
• MDL number: MFCD11655778
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: ethanol: 10 mg/mL; DMSO: 25 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: Brc1c(ccc(c1)\C=C2/CCC\C(=C/c3cc(c(cc3)O)Br)\C/2=O)O
• InChI: 1S/C20H16Br2O3/c21-16-10-12(4-6-18(16)23)8-14-2-1-3-15(20(14)25)9-13-5-7-19(24)17(22)11-13/h4-11,23-24H,1-3H2/b14-8+,15-9+
• InChI key: YOLKEKNTCBWPSD-VOMDNODZSA-N

설명

일반 설명

A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC₅₀ = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC₅₀ ≤ 40 µM) and induce chromatin condensation in HeLa cells.

A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC₅₀ = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC₅₀ ≤40 µM) and induce chromatin condensation in HeLa cells.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.

기타 정보

Costi, R., et al. 2007. J. Med. Chem.50, 1973.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable