344847

Fumitremorgin C

from Aspergillus. fumigatus, ≥95% (HPLC), lyophilized, BCRP/ABCG2 inhibitor, Calbiochem^®

• 동의어(들): Fumitremorgin C, Aspergillus. fumigatus, NSC719655, FTC
• 실험식(Hill 표기법): C₂₂H₂₅N₃O₃
• CAS Number: 118974-02-0
• Molecular Weight: 379.45
• MDL number: MFCD08702652
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: Fumitremorgin C, Aspergillus. fumigatus, A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity.
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: lyophilized
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• solubility: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: N21[C@@H](Cc4c5c([nH]c4[C@@H]2C=C(C)C)cc(cc5)OC)C(=O)N3[C@@H](CCC3)C1=O
• InChI: 1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3/t17-,18-,19-/m0/s1
• InChI key: DBEYVIGIPJSTOR-FHWLQOOXSA-N

설명

일반 설명

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Toxic (F)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Allen, J.D., et al. 2002. Mol. Cancer Ther.1, 417.
Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun.285, 111.
Rabindran, S.K., et al. 2000. Cancer Res.60, 47.
Rabindran, S.K., et al. 1998. Cancer Res.58, 5850.
Cole, R.J., et al. 1977. J. Agric. Food Chem.25, 826.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable