343922

5-Fluorouracil

≥98% (HPLC), solid, thymidylate synthase inhibitor, Calbiochem^®

• 동의어(들): 5-Fluorouracil, 5-FU
• 실험식(Hill 표기법): C₄H₃FN₂O₂
• CAS Number: 51-21-8
• Molecular Weight: 130.08
• MDL number: MFCD00006018
• UNSPSC 코드: 12171500
• NACRES: NA.77

속성

• 제품명: 5-Fluorouracil, Potent antitumor agent.
• 설명: Merck USA index - 14, 4181
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: hot water: 1 mg/mL; methanol: 1 mg/mL; DMF: 5 mg/mL; DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: Fc1[c]([nH][c]([nH]c1)=O)=O
• InChI: 1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
• InChI key: GHASVSINZRGABV-UHFFFAOYSA-N

설명

일반 설명

Potent antitumor agent that inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis of human colon cancer cell lines.

Potent antitumor agent. Inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis in human colon cancer cell lines.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Aminoisobutyrate-pyruvate aminotransferase

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Harmful (C)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Pressacco, J., et al. 1996. Br. J. Cancer72, 939.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H351
• 예방조치 성명서: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3