310500

D-erythro-Sphingosine, N,N-Dimethyl-

A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity.

• 동의어(들): D-erythro-Sphingosine, N,N-Dimethyl-, DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
• 실험식(Hill 표기법): C₂₀H₄₁NO₂
• CAS Number: 119567-63-4
• Molecular Weight: 327.55
• MDL number: MFCD02259309
• UNSPSC 코드: 12352211
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (TLC)
• 양식: oil (Clear); waxy solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• solubility: DMSO: 5 mg/mL; ethanol: soluble; methanol: soluble
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: N([C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO)(C)C
• InChI: 1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
• InChI key: YRXOQXUDKDCXME-YIVRLKKSSA-N

설명

일반 설명

A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.

A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
PKC

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 12 µM against PKC

경고

Toxicity: Irritant (B)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

기타 정보

Cuvillier, O., et al. 1996. Nature381, 800.
Ohta, H., et al. 1995. Cancer Res.55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et al. 1991. Biochemistry30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable