260585

5′-Deoxy-5′-methylthioadenosine

≥98% (HPLC), solid, MTAP substrate, Calbiochem^®

• 동의어(들): 5′-Deoxy-5′-methylthioadenosine, MTA, MeSAdo
• 실험식(Hill 표기법): C₁₁H₁₅N₅O₃S
• CAS Number: 2457-80-9
• Molecular Weight: 297.33
• MDL number: MFCD04220941
• UNSPSC 코드: 12352208
• NACRES: NA.77

속성

• 제품명: 5′-Deoxy-5′-methylthioadenosine, A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP).
• Quality Level: 100
• 설명: RTECS - AU7410000
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: DMF: 25 mg/mL; DMSO: soluble
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: S(CC1OC(C(C1O)O)[n]2c3ncnc(c3nc2)N)C
• InChI: 1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)
• InChI key: WUUGFSXJNOTRMR-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.

A naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.

생화학적/생리학적 작용

Primary Target
protein carboxymethyltranferase

Secondary Target
FGF-2receptor tyrosine kinase activity

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

재구성

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Lee, S.H., and Cho, Y.D. 1998. Exp. Cell Res.240, 282.
Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res.51, 53.
Joy, A., et al. 1997. Oncogene14, 171.
Riscoe, M.K., et al. 1984. Biochem. Pharmacol.33, 3639.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable