219433

Cathepsin L Inhibitor IV

The Cathepsin L Inhibitor IV controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 동의어(들): Cathepsin L Inhibitor IV, 1-Naphthalenesulfonyl-IW-CHO
• 실험식(Hill 표기법): C₂₇H₂₉N₃O₄S
• Molecular Weight: 491.60
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white to off-white
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Also inhibits the release of Ca²⁺ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Inhibits the release of Ca²⁺ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
cathepsin L

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 1.9 nM against Cathepsin L

경고

Toxicity: Standard Handling (A)

서열

1-Naphthalenesulfonyl-Ile-Trp-CHO

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable