219419

Cathepsin Inhibitor III

The Cathepsin Inhibitor III controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 동의어(들): Cathepsin Inhibitor III, Z-FG-NHO-BzOME
• 실험식(Hill 표기법): C₂₇H₂₇N₃O₇
• Molecular Weight: 505.52
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: >90% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated; protect from light
• 색상: white
• solubility: ethanol: 1 mg/mL; DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 10-30°C

설명

일반 설명

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1 x 10⁴ M^-1 sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1 sec^-1), cathepsin S (k₂/K_i = 6.6 x 10⁴ M^-1 sec^-1), and papain (k₂/K_i = 1 x 10³ M^-1 sec^-1).

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1.0 x 10⁴ M^-1sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1sec^-1), cathepsin S (k₂/Ki = 6.6 x 10⁴ M^-1sec^-1), and papain (k₂/K_i = 1.0 x 10³ M^-1sec^-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

k₂/K_i = 1 x 10⁴ M⁻¹ sec⁻¹

경고

Toxicity: Standard Handling (A)

서열

Z-Phe-Gly-NHO-Bz-pOMe

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable